In 2008, he was seen in Kukunoor's cross-cultural comedy film, Bombay To Bangkok. In 2006, he starred in the comedy, Apna Sapna Money Money and in 2007, he starred in Farah Khan's blockbuster movie, Om Shanti Om, with Shah Rukh Khan, where he played the role of Pappu Master.

This film was also well received by critics. His next film was Kukunoor's Dor in which he played the comic role of a behroopiya, a man with many disguises. The film and his performance were well received by both audiences and critics. Fame arrived after he made his Bollywood debut in Nagesh Kukunoor's Iqbal which was written by Vipul K Rawal in which he played the role of a deaf & mute youngster aspiring to be a cricketer.

He also appeared in Jaane Anjaane (2001) aired on doordarshan where he played the role of a son who dislikes his father because he felt that his father was the reason for his accident. His role, in a very popular Marathi serial Damini, as the character Tejas was very popular among Marathi audiences. He has also acted in mini-serials for the production 'Adhikari Brothers'. He also appeared in the Zee TV soap opera Woh (1998) in which he was the main lead. Talpade began his acting career appearing in Marathi soap operas and doing stage shows across Maharashtra.

He is married to Deepti Talpade, a psychiatrist. Shreyas attended Shree Ram Welfare Society’s High School in Andheri West followed by Mithibai College in Vile Parle. His father is the brother of actresses Meena T. Shreyas Talpade was born in Mumbai, Maharashtra on 27 January 1976.

Bedhund Manachi Lahar Marathi Serial